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Large clinical trials comparing these medications to levodopa showed that they can be used in early Parkinson's disease and reduce the severity of symptoms.

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Patients with early parkinsonian syndrome (without levodopa): Nausea, dizziness, somnolence, insomnia, asthenia, fatigue, muscle spasms, dry mouth, constipation, hallucinations, general edema, peripheral edema.

Population pharmacokinetic analysis suggests that coadministration of drugs that are secreted by the cationic transport system (e.

However, amineptine is no longer available as a treatment for depression due to reports of an abuse potential.

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